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The structure highlights the distinctive triple-proline motif (Pro-Pro-Pro) at positions 3-5 that contributes to the peptide's remarkable stability

An alteration in the phosphorylation pattern, such as an increase in tyrosine phosphorylation, which results from pathological conditions, such as inflammation or elevated ROS, can alter the proteinprotein interactions of occludin with ZO-1, ZO-2, and ZO-3, and thereby alter the membrane integrity 75

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